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Studies Link Bayer's Trasylol to Stroke and Heart Attack

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Case ID: 4643 | Drugs / Medical | 02/06/2006
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Have you or a family member taken trasylol and suffered kidney damage or heart attack or stroke?

A major independent study indicates Bayer's antifibrinolytic agent Trasylol doubles the risk of kidney failure and causes other serious adverse events, including stroke and heart attack. Trasylol has been on the market for 13 years, and it reduces the loss of blood during surgery and is typically used during certain heart operations.

"The study raises serious questions about the continued use of Trasylol and suggests far less expensive alternatives are available that are equally effective and safe,"said the study's lead author, Dennis Mangano, also a member of the Ischemia Research and Education Foundation in California. Two generic drugs, aminocaproic acid and tranexamic acid were just as effective and safer, the research team concluded.

The study found that using one of the generic drugs instead of Trasylol worldwide could prevent as many as 11,050 dialysis complications, save $1 billion in healthcare costs and reduce drug costs by $250 million.

The team also estimates that as many as 10,000 patients may now be on dialysis due to Trasylol. The life-threatening side effects associated with Trasylol occurred more frequently than those associated with Merck's Vioxx, which was taken off the market in 2004 after it was linked to an increased risk of heart attacks and strokes.

Clinical Study

In a recent study, data was collected from more than 4,300 patients undergoing revascularization surgery at more than 69 centers around the world between 1996 and 2000. The patients received either Trasylol, aminocaproic acid, tranexamic acid or no treatment. The Trasylol group had double the risk of renal failure requiring dialysis usually observed in patients undergoing complex coronary-artery surgery or primary surgery. The group also had a 48-percent increased risk of heart attack, a 109-percent increased risk of heart failure and a 181-percent increased risk of stroke or encephalopathy.

The recent study comes as a blow to the German owned Bayer, which is pushing to have the drug used in all surgeries, not just in cases where there is a risk of excessive blood loss.

If you or a family member suffered kidney failure, heart attack or stroke while on Trasylol, our attorneys may be able to assist you.


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